Multidimensional QSAR Modeling of Amprenavir Derivatives as HIV-Protease Inhibitors
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چکیده
منابع مشابه
Multidimensional QSAR Modeling of Amprenavir Derivatives as HIV-Protease Inhibitors
A computational study has been performed on a series of 55 compounds having (S)-N-(3-(N-(cyclopen-tylmethyl) substituted-phenylsulfonamido)-2-hydroxypropyl) acetamide backbone as HIV-1 protease inhibitors. Various combinations of these specific inhibitors fragments were formed by breaking them at central alicyclic single bonds, while retaining the core. Standard Topomer 3D models were automatic...
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Preventing and reducing the spread of HIV (HIV) has always been a concern in medical science. One of the most common ways to control the virus is using enzyme-blocking drugs. In this study, we attempted to predict the biological activity (PKi) of organic urea derivatives in protease inhibitor compounds using molecular modeling using QSAR (Quantitative Structure Activity Relation), which is the ...
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ژورنال
عنوان ژورنال: Open Journal of Medicinal Chemistry
سال: 2011
ISSN: 2164-3121,2164-313X
DOI: 10.4236/ojmc.2011.11001